A Brief Account on Recent Advancements and Applications of NMR Spectroscopy

The present book chapter has highlighted the various types of NMR spectroscopy, including solid-state NMR, solution-state NMR, and their applications in hybridization with other spectroscopic techniques in pharmaceutical analysis, drug discovery, and impurity profiling. NMR has been a powerful tool for both drug discovery and the study of the structure and dynamics of biomolecules in conjunction with X-ray crystallography. Along with other chemometric techniques like principal component analysis, discriminant analysis, and partial least square regression are used. In the pharmaceutical sector, NMR has been found to be much important in determining the purity of medications with their various variants, the validity of herbal products/heparin, fingerprinting of isotopes, etc.

Keywords: Applications of NMR, NMR spectroscopy, Nuclear magnetic resonance, Organic compounds, Solid-state NMR.