Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Christopher A. Lipinski formulated a rule based on his observation that most drugs administered orally are relatively small and moderately lipophilic molecules. This rule serves as a guideline to determine whether a molecule with specific pharmacological or biological activity possesses properties that would make it a viable orally active drug in humans. Lipinski's Rule of Five functions as a powerful screening tool in the initial phases of drug discovery, enabling researchers to pick molecules with ideal attributes for subsequent development and testing.
Keywords:
Absorption, Acceptors, Biological activity, Donors, Exceptions drugability, Lipinski’s rule of five.
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Authors:Bentham Science Books