Lipinski’s Rule of Five

Christopher A. Lipinski formulated a rule based on his observation that most drugs administered orally are relatively small and moderately lipophilic molecules. This rule serves as a guideline to determine whether a molecule with specific pharmacological or biological activity possesses properties that would make it a viable orally active drug in humans. Lipinski's Rule of Five functions as a powerful screening tool in the initial phases of drug discovery, enabling researchers to pick molecules with ideal attributes for subsequent development and testing.