Abstract
Phyto-nanotechnology presents a promising avenue for revolutionizing rheumatoid arthritis (RA) treatment. By integrating plant-derived compounds with nanotechnology, this approach addresses the limitations of conventional RA therapies. Nanoformulations of phytochemicals, such as curcumin, resveratrol, and quercetin, enable targeted drug delivery to inflamed joints, optimizing therapeutic efficacy while minimizing systemic side effects. Enhanced bioavailability, attributed to the encapsulation of phytochemicals within nanoparticles, facilitates improved pharmacokinetics and delivery across biological barriers. The immunomodulatory and anti-inflammatory properties of phytochemicals are harnessed more effectively through nanoparticle-mediated sustained release, offering the potential to suppress inflammatory processes and mitigate joint damage. Furthermore, the cartilageprotective and regenerative capabilities of certain plant-derived compounds can be optimized with nanotechnology, promoting joint health. The versatility of phytonanotechnology allows for combination therapies, synergizing the benefits of multiple compounds and conventional drugs within nanoparticles. While these advancements hold substantial promise, further research is imperative to refine nanoparticle formulations, assess safety, and validate efficacy through preclinical and clinical studies, ultimately paving the way for transformative RA treatments in clinical practice. In this chapter, phyto-nano drug delivery systems that can increase the effectiveness of medicinal plants in RA treatment are focused on.