Chapter - Research Outcomes of Natural Products in Diabetes Mellitus | Bentham Science

Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules

Author(s): Subrat Kumar Bhattamisra* and Mayuren Candasamy

DOI: 10.2174/9789815238129124030007

Research Outcomes of Natural Products in Diabetes Mellitus

Pp: 148-198 (51)

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Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules

Research Outcomes of Natural Products in Diabetes Mellitus

Author(s): Subrat Kumar Bhattamisra* and Mayuren Candasamy

Pp: 148-198 (51)

DOI: 10.2174/9789815238129124030007

* (Excluding Mailing and Handling)

Abstract

Diabetes mellitus, is a chronic condition with dysregulated glucose levels and has been affecting a larger global population. The disease, if not controlled, can lead to several microvascular and macrovascular complications that will impede the patients' physical and mental well-being in addition to its economic burden. Many diabetic patients are unaware of the complications and hesitate to take medicines in the early phase of the disease condition. Furthermore, many patients have limited access to conventional antidiabetic drugs, which drives the search for newer agents or relying on alternative/complementary medicines. Ancient systems such as Ayurveda, traditional African and Chinese medicine, Japanese Kampo medicine, and other systems of medicine have identified many herbal/plants, and mineral-based agents for treating diabetes. Many such plants probably more than 800 and their extracts have been scientifically proven or tested using various experimental models of diabetes in animals. Despite several In vitro and In vivo studies reporting the effects of extracts of plants on blood glucose, only a few trials have been performed to validate their efficacy in treating humans with diabetes. An apparent mismatch in outcomes was observed while translating the effectiveness of these plants from an experimental animal study to a human study. These inconsistencies among animal and human studies were remarkable in some cases. There are several aspects responsible for these variations, such as variation in plant parts/extracts, dose, duration in different studies, the difference between animal models and human disease, and initiation of drug treatment in animal model, which is generally before the induction of diabetes or immediately after the induction of diabetes. This chapter focuses on the animal studies and human clinical trials conducted on plant-based extracts and other natural products and the outcomes in controlling or managing diabetes mellitus.

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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59945107 and j.to_ip >=59945107 )) and ((j.from_date <= 1737320819 and j.to_date >= 1737320819 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 23486) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59945107 and j.to_ip >=59945107 )) and ((j.from_date <= 1737320819 and j.to_date >= 1737320819 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 23486) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59945107 and j.to_ip >=59945107 )) and ((j.from_date <= 1737320819 and j.to_date >= 1737320819 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 23486)
      520μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1548
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3785 and `b`.`banner_from_date` <= 1737320819 and `b`.`banner_to_date` >= 1737320819 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.04msalphaeurekaselec_live_10_06_2022Banner.php#189
      Bindings
      • 0: 1
      • 1: B
      • 2: 3785
      • 3: 1737320819
      • 4: 1737320819
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:189
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='03ad167bf5472bf3c4b6c78e68ba6954'
      210μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._main_menu:13
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        dyHjcQ7HXIHb1aBdPG0C0tWwM1itaM7Iy08pg88D
        uc_cart_id
        03ad167bf5472bf3c4b6c78e68ba6954
        _previous
        array:1 [ "url" => "https://beta.benthamscience.com/chapter/23486" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/23486
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:16 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "beta.benthamscience.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
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        array:5 [ "_token" => "dyHjcQ7HXIHb1aBdPG0C0tWwM1itaM7Iy08pg88D" "uc_cart_id" => "03ad167bf5472bf3c4b6c78e68ba6954" "_previous" => array:1 [ "url" => "https://beta.benthamscience.com/chapter/23486" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-01-19 21:06:59GET/chapter/23486111192