Anticancer Drugs Sourced from Marine Life

Author(s): Ramasamy Santhanam*, Santhanam Ramesh*, Subbiah Balasundari* and Sheba R. David * .

DOI: 10.2174/9789815256055124010010

Anticancer Potential of Marine Shellfish

Pp: 231-296 (66)

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  • * (Excluding Mailing and Handling)

Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

This topic describes the anticancer metabolites of the components of marine shellfish such as crustaceasn (shrimp, lobsters, crayfish, and crabs), marine molluscs viz. bivalves (clams, oysters, etc), gastropods (snails, slugs, etc.) and cephalopods (squids, octopuses, and cuttlefish). Among the bioactive compounds of marine molluscs, the anti-proliferative and cytotoxic compounds accounted for 12 and 36%. Among echinoderms, the asteroids (starfish), echinoids (sea urchins) and holothuroids (sea cucumbers) are found to be pharmaceutically important. Among the bioactive metabolites of echinoderms, the cytotoxic or anti-proliferative metabolites accounted for 38%. 

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