Advances in Diagnostics and Immunotherapeutics for Neurodegenerative Diseases

Author(s): Sumel Ashique*, Radheshyam Pal, Shubneesh Kumar, Bharti Verma, Nitish Kumar, Ivan Kahwa, Arshad Farid, Neeraj Mishra*, Prashant Kumar and Farzad Taghizadeh-Hesary

DOI: 10.2174/9789815238754124010009

Interplay Between Gut-microbiota and Neurodegeneration

Pp: 104-145 (42)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Introduction: The body of scientific evidence linking the microbiome to many diseases has grown dramatically over the past several years; neurological diseases have also shown a similar tendency. As a result, the gut-brain axis theory as well as the notion that there could be a connection between the gut microbiome and several CNS-related disorders whose pathophysiology is still not known have both emerged.

Development: We look at the role played by gut microbiomes in the gut-brain axis as well as the neurological conditions neuromyelitis optica, Alzheimer's, amyotrophic lateral sclerosis, Parkinson's, and multiple sclerosis, where changes in the gut microbiota have been linked to human studies.

Conclusions: The amount of data connecting gut microbiota to different neurological illnesses has significantly increased. Today, there is no longer any doubt that the gut microbiota of the host influences brain function. This review assembles a sizable body of credible research that is essential in emphasizing the crucial role of microbiota colonization in neurodevelopment and how changes in microbiota dynamics might have an age-dependent effect on brain function.

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