Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Taking a step forward from the indicator spacer receptor (ISR) method
comprising covalent linkages between receptors and indicators via a spacer, the
indicator displacement assay (IDA) offers an innovative and powerful sensing
approach for various target analytes in the realm of host-guest chemistry. In this
chapter, we have assembled the background and conceptual details in order to give
essence to the readers about this innovative sensing approach. The photophysical
phenomenon and diverse non-covalent interactions involved in the sensing mechanism
have been detailed. We have elucidated the need and urgency to replace the ISR
approach with IDA, one having numerous advantages. The evolutionary extension of
IDA for enzymatic conversion known as supramolecular tandem assays has also been
described in this chapter. We believe that the present introductory chapter will give a
better understanding to readers who are new to this field.
Keywords:
Analyte, Competitive binding, Dynamic, Detection, Enantiomeric excess, Enzyme, Fluorescence quenching, Guest, Host, Indicator displacement assay, Indicators, Macrocycle, Non-covalent interaction, Receptors, Reversible, Recognition, Sensors, Signal, Substrate, Tandem assays.
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Authors:Bentham Science Books