Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
The objective of the study was to identify a potential inhibitor for
Bifunctional Protein in Microcystisaeruginosa. The in silico modeling of the protein
using the “TBM” module of “Galaxy Seok Lab” extended the execution of virtual
screening using MTi open screen. Finally, the protein-ligand interaction was studied
using LIGPLOT software for “Bifunctional Protein” in “Microcystis aeruginosa.” The
virtual screening revealed 7176 compounds from the drug library, and the “best fit”
screening resulted in 1500 compounds. Among the 1500 compounds, the molecule
MK-3207 showed a better affinity towards the bifunctional Protein with -11.3Kcal/mol
binding energy.
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Authors:Bentham Science Books