Fundamentals of Cellular and Molecular Biology

Author(s): Itrat Fatima Toor * .

DOI: 10.2174/9789815238037124010010

DNA Polymorphisms and Genetic Fingerprint

Pp: 97-110 (14)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

DNA polymorphisms are variations in the genetic sequence that occur within a population. These polymorphisms can be used as genetic markers to identify individuals, determine familial relationships, and study population genetics. Genetic fingerprinting is a widely used method for identifying individuals based on DNA polymorphisms. Genetic fingerprinting involves the analysis of DNA polymorphisms at multiple loci to generate a unique genetic profile for an individual. The most common types of DNA polymorphisms used for genetic fingerprinting are short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs). STRs are short, repeated sequences of DNA that vary in length between individuals. They are highly polymorphic and generate DNA profiles by analyzing the number of repeats at each locus. SNP markers, on the other hand, are single nucleotide variations that occur at specific positions within the genome. They are less polymorphic than STRs, but genetic mapping and association studies are widely used. Genetic fingerprinting has many applications, including forensic science, paternity testing, and conservation biology. However, the use of genetic data also raises ethical concerns regarding privacy and discrimination.

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