Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
The development of more intricately constructed molecules and drug
delivery systems as a result of technological breakthroughs has increased our
understanding of the complexities of disease and allowed us to identify a wide range of
therapeutic targets. New drug combinations can be designed by correctly using
dynamical systems-based PK/PD models. The unswerving approach that offers a better
knowledge and understanding of therapeutic efficacy and safety is the use of
pharmacokinetic-pharmacodynamic (PK-PD) modeling in drug research. In vivo,
animal testing or in vitro bioassay is used to forecast efficacy and safety in people.
Model-based simulation using primary pharmacodynamic models for direct and
indirect responses is used to elucidate the assumption of a fictitious minimal effective
concentration or threshold in the exposure-response relationship of many medicines. In
this current review, we have abridged the basic PK-PD modeling concepts of drug
delivery and documented how they can be used in current research and development.
Keywords:
Clinical development, Modeling, Pharmacokinetics, Pharmacodynamics, Preclinical.
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Authors:Bentham Science Books