Functional Bio-based Materials for Regenerative Medicine: From Bench to Bedside (Part 2)

Author(s): Ubashini Vijakumaran, Nur Atiqah Haron, Heng J. Wei, Mohamad Fikeri Ishak and Nadiah Sulaiman * .

DOI: 10.2174/9789815179330124010019

Cells in Vascular Tissue Engineering Research

Pp: 273-284 (12)

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* (Excluding Mailing and Handling)

  • * (Excluding Mailing and Handling)

Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Fabrication of off-the-shelf small diameter vascular graft as an alternative to current autologous graft in clinical setting i.e., internal mammary artery and saphenous veins has yet to be perfected. With cardiovascular diseases (CVD) topping the list of the causes of death worldwide, alternative vascular graft is especially crucial in patients with a lack of autologous grafts. Successful re-vascularisation could substantially lower the progression of CVD and mortality rate. This chapter delves into cells that are vital in developing a tissue engineered vascular graft (TEVG), ranging from the native tissue on the vascular bed to the potential cells that could be utilized, compounds that possibly could improve the available grafts and stents and future TEVG design.

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