Functional Bio-based Materials for Regenerative Medicine: From Bench to Bedside (Part 2)

Author(s): Wan Kartini binti Wan Abdul Khodir and Mohd Reusmaazran bin Yusof * .

DOI: 10.2174/9789815179330124010016

3D-Scaffold Design of Biodegradable Nanofibers for Tissue Regeneration and Drug Delivery

Pp: 212-232 (21)

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  • * (Excluding Mailing and Handling)

Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Materials with specific properties and structures are required for 3D nanofibers scaffold to perform well during tissue regeneration and drug delivery applications. When designing and fabricating 3D scaffolds, it is crucial to consider how the biomaterials interact with the native tissue structures and how they function in the surrounding environment. This chapter provided a brief discussion on the fabrication methods used to construct 3D biodegradable polymeric nanofibers scaffolds through electrospinning from 2D structures. Further, it extended to the characterisation required for the scaffold to be used in either tissue engineering or drug delivery. Additionally, this chapter presented recent progress in the practical application of 3D scaffolds that incorporate different therapeutic agents.

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