Functional Bio-based Materials for Regenerative Medicine: From Bench to Bedside (Part 2)

Author(s): Jun W. Heng, Ubashini Vijakumaran, Rohaina C. Man and Nadiah Sulaiman * .

DOI: 10.2174/9789815179330124010010

Scaffolds in Vascular Tissue Engineering Research

Pp: 119-139 (21)

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* (Excluding Mailing and Handling)

  • * (Excluding Mailing and Handling)

Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Scaffolds represent one of the key components in the tissue engineering triad. Construction of a vascular graft begins with the scaffold that acts as the base building material. Whether natural or synthetic, selecting the right scaffold material is essential to ensure the structural integrity of a graft. The structural integrity could further be strengthened with the addition of cells and regulatory signals that make up the whole tissue engineering triad. In this chapter, a selection of scaffold materials is discussed, and cell seeding strategies are later elaborated, covering the principle of the tissue engineering triad in vascular research.

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