Medicinal Plants, Phytomedicines and Traditional Herbal Remedies for Drug Discovery and Development against COVID-19

Author(s): Iqra Yasmin*, Wahab A. Khan, Ayesha Manzoor, Muhammad W. Iqbal and Muhammad Azam

DOI: 10.2174/9789815049510123010006

Plant Sources of Pro and Anti-Inflammatory Mediators against COVID-19

Pp: 91-109 (19)

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Medicinal Plants, Phytomedicines and Traditional Herbal Remedies for Drug Discovery and Development against COVID-19

Plant Sources of Pro and Anti-Inflammatory Mediators against COVID-19

Author(s): Iqra Yasmin*, Wahab A. Khan, Ayesha Manzoor, Muhammad W. Iqbal and Muhammad Azam

Pp: 91-109 (19)

DOI: 10.2174/9789815049510123010006

* (Excluding Mailing and Handling)

Abstract

The first and the most vital biotic response of the immune system against stress, oxidation, infection, injury and irritation is inflammation. Reports revealed that the anti-inflammatory effect is mediated by various inflammatory cytokines and non-cytokine mediators i.e. tumor necrosis factor alpha-a, nitric oxide, interleukins, interferon gamma-g, and prostaglandin E2 respectively. Herbal medicine is playing an important role in the treatment of COVID-19. Plant-based foods are rich source of bioactive compounds (phytochemicals) and have a potential anti-inflammatory effect. The purpose of this chapter is to sum up the recent findings of work already done both in vitro and in vivo on the anti-inflammatory effects of plant-based foods. As a source of natural modulators of gene expressions, phytochemicals from plants could be used along with other pharmaceutical formulations as anti-inflammatory drugs. Therefore, the regulation of inflammation by modulating the pro-inflammation and anti-inflammation cytokine expression through different plant-based food also boosts immunity.