Frontiers In Medicinal Chemistry

Author(s): Ravi S. Singh* and Sanjay Kumar

DOI: 10.2174/9789815165043123100011

Shikonin, a Naphthaquinone of Commercial Importance: its Biosynthesis and Prospect for Use as Drugs

Pp: 233-248 (16)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Shikonin is a red naphthaquinone pigment present in the roots of plants of the Boraginaceae family. This pigment is an as active ingredient in several pharmaceutical and cosmetics preparations, and as a dye for fabrics and food items. It shows many bioactivities such as stimulation of peroxidase, protection against UV-radiation, inhibition of microsomal monooxygenase and induction and secretion of nerve growth factor. In this book chapter, we have provided detailed information on its biosynthesis and prospects for pharmaceutical use.

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