Frontiers In Medicinal Chemistry

Author(s): Sachin Verma, Pallavi Kumari, Shailesh Kumar and Ashok Kumar Jha * .

DOI: 10.2174/9789815165043123100009

Carcinogenicity of Hexavalent Chromium and Its Effects

Pp: 205-213 (9)

Buy Chapters

* (Excluding Mailing and Handling)

  • * (Excluding Mailing and Handling)

Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Hexavalent chromium has been a potential threat to human beings due to its toxicity and carcinogenesis. The pathway of entry of hexavalent chromium in an aqueous medium is both anthropogenic and natural through ores of chromium. Prolonged exposure to hexavalent chromium may cause DNA mismatch and gene mutation, resulting in cancer. Cr(VI)- induced malignant cell and its study has become very important towards the possible mechanism of Cr(VI) binding. When a cell of the human lungs adsorbs hexavalent chromium due to prolonged ingestion of Cr(VI) contaminated water or inhalation, oxidative DNA damage is caused in the specific gene. This causes mutations in adenine and guanine bases of DNA in cases of lung cancer.

We recommend

Favorable 70-S: Investigation Branching Arrow

Authors:Bentham Science Books