Recent Advances in the Application of Marine Natural Products as Antimicrobial Agents

Author(s): Arumugam Priya, Nagaiah Hari Prasath and Shunmugiah Karutha Pandian * .

DOI: 10.2174/9789815080148123030015

Bioactive Polysaccharides with Antimicrobial Proficiency from Marine Environment

Pp: 278-303 (26)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Marine environment upholds vast biodiversity, which also acts as a treasurer of a huge variety of bioactive molecules. Bioactive components of marine origin range from peptides, lipids, fatty acids, proteins, minerals, phenolic compounds, vitamins, terpenoids, polyketides, polysaccharides etc. Marine-derived peptides have been explored to a larger extent for their biological applications. In recent years, polysaccharides, one of the essential macromolecules in all forms of living, have been gaining attention for their relevance in biological applications. Among the polysaccharides derived from various living forms, marine-derived polysaccharides are effective in terms of their biological activities owing to their structural diversity, composition, availability etc. Marine polysaccharides exhibit a broad spectrum of biological and pharmacological activities ranging from anti-inflammatory, antioxidant, anticancerous, antidiabetic, antioxidant, antidiabetic and immunomodulatory activities. Additionally, these bioactive polysaccharides also exert antimicrobial activities against a broad range of clinically important pathogenic organisms. Due to their excellent antimicrobial activities, marine polysaccharides, their sulfated derivatives and polysaccharide-based nanoparticles are gaining attention in biomedical applications such as wound dressing, drug delivery, tissue engineering etc.

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