Abstract

Due to the increase in cancer cases nowadays, an increase in studies related to treatment has been observed. Although many natural or synthetic compounds have been described as therapeutic today, the effects of these treatments are seen in both healthy and cancer cells. In order to reduce these undesirable effects seen in chemotherapy and radiotherapy, alternative treatments that have less effect on healthy cells or alternative attitudes that will allow the minimum use of therapeutics in these treatments continue to be investigated. In particular, such studies focus on natural compounds with phenolic properties. This chapter focuses on the relationship between coumarin derivatives, curcumin, Olea europaea leaf extract, and Cynara scolymus leaf extract with hepatocellular carcinoma. Furthermore, the effect of these natural compounds on the genetic hallmarks of various signalling pathways and important cellular metabolism molecules of hepatocellular carcinoma are discussed.