Toll-Like Receptors in Vector-borne Diseases

Author(s): Jayalakshmi Krishnan * .

DOI: 10.2174/9789815124545123010006

TLRs in Lymphatic Filariasis

Pp: 26-30 (5)

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  • * (Excluding Mailing and Handling)

Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Lymphatic filariasis is one of the neglected tropical diseases and also a disfiguring vector-borne disease. Parasitic nematodes such as Wuchereriabancrofti, Brugiamalayi, and Brugiatimori are the three types of parasites that cause lymphatic pathology in terms of hydrocele, lymphedema, and elephantiasis [1]. Among these three parasites, Wuchereriabancrofti is the principal parasite, which causes around 90% of infections. These nematodes impair the lymphatic system, thus leading to considerable morbidity in the affected people. The life cycle of this adult-stage lymphdwelling parasites is complex in nature. Once they start infecting the lymphatics, they cause swelling, dilatation, and thickening of lymph vessels.

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