Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Cancer is characterized by atypical cell proliferation that has the possibility
of dissemination to different body parts. Tumor formation is influenced by genetic
mutations and environmental pollutants. The formation and progression of
malignancies have been linked to a diversity of molecular paths. The JAK/STAT,
NOTCH, PI3K/AKT pathway, mitogen-activated protein kinase (MAPK), transforming
growth factor-beta (TGF-beta) (TGF-), NF-B, and Wnt signaling pathways will be
highlighted in this chapter. Cancer development has been linked to various changes to
the signaling pathways' components. As a result, various initiatives to target signaling
pathways in order to build distinct treatment lines have been approved. In this chapter,
we discuss the role of signal transduction in cancer-associated processes and how their
targets influence the behavior of the tumor cells.
Keywords:
Cancer, JAK/STAT, Map Kinase/Erk, NFκB, Notch, PI3K/AKT/mTOR, TGF-β, Wnt/β catenin.
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Authors:Bentham Science Books