Microcirculation and Insulin Resistance

Author(s): Erik H Serne, Rick I Meijer, Michiel P de Boer, Renate T de Jongh, Richard G IJzerman, Wineke Bakker and Etto C Eringa

DOI: 10.2174/978160805057410901010041

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Microvascular Dysfunction: Potential Role in the Pathogenesis of Obesity-Associated Hypertension and Insulin Resistance

Pp: 41-54 (14)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

The intertwined epidemics of obesity and related disorders such as hypertension, insulin resistance, type 2 diabetes, and subsequent cardiovascular disease pose a major public health challenge. To meet this challenge, we must understand the interplay between adipose tissue and the vasculature. Microvascular dysfunction is important not only in the development of obesityrelated target-organ damage, but also in the development of cardiovascular risk factors such as hypertension and insulin resistance. The present chapter examines the role of microvascular dysfunction as an explanation for the associations among obesity, hypertension and impaired insulin-mediated glucose disposal. We also discuss communicative pathways from adipose tissue to the microcirculation.

Keywords:

Obesity, hypertension, insulin resistance, microcirculation.

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