Bioactive Phytochemicals from Himalayas: A Phytotherapeutic Approach

Author(s): Kavita, Naina Rajak, Praveen Kumar, Shikha Singh and Neha Garg * .

DOI: 10.2174/9789815123289123010011

Immunomodulatory Potential of Himalayan Plant: Withania somnifera

Pp: 105-116 (12)

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  • * (Excluding Mailing and Handling)

Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Withania somnifera, a herb used in Ayurveda since ancient times, is commonly found in the Himalayan belt. Withania somnifera is reported to be useful in fever, arthritis, asthma, bronchitis, tuberculosis, syphilis, and cancers. Its leaves are found to be effective against swelling, chest pain, sores, and ulcers. Withania possesses antioxidant, immunomodulatory, anti-inflammatory, anti-stress, anti-bacterial, antimicrobial, anti-fungal, anti-tumor, adaptogenic, and memory-enhancing properties. Among the bioactive compounds present in Withania, Withaferin A is the most important and well-explored compound having anti-cancer activity among several other activities. Many studies have reported the anti-inflammatory action of Withania somnifera and isolated Withaferin A. In this chapter, we have summarized the antiinflammatory activities exhibited by this multifaceted medicinal plant.

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