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This chapter covers the use of glycosylphosphatidylinositol (GPI)-anchored proteins for surface modification of diverse types of biomembrane covered entities ranging from viruses and virus-related particles (section 1), to cells (section 2) and other natural and engineered micro- and nano-scaled particles (section 3). The aim is to present and review state-of-the-art research in this area and to discuss the future direction of GPI painting technology relating to applications in research, biotechnology and biomedicine.
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