Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
The delivery system plays a vital role in managing the pharmacokinetics and
pharmacodynamics of a drug. The size of the carrier system contributes to its
pharmacological action. Lipid-based carriers refer to the formulations containing a
dissolved or suspended drug in lipidic excipients. Lipoidal systems as carriers are
achieving heights due to their significant lipid nature and the size of particles in the
delivery system. The micro/nano-sized lipid-based carriers possess versatility in
improving the physic-chemical properties of drugs. Also, they are biocompatible and
can be administered through all possible routes. Lipid-based drug delivery carrier
systems of new and existing formulations can be commercialized to achieve the desired
range of product specifications. Solubility of the drug in various lipids is a key factor in
the development of the delivery system. Lipids as functional excipients are compatible
with solid, liquid, and semi-solid dosage forms. Besides improving/enhancing the
solubility and bioavailability, lipids provide multiple broad-based applications in the
pharmaceutical delivery system.
Keywords:
Bioavailability, BCS Class, Cancer, Carriers, Delivery system, Lipids, Micro/nano, Pharmacokinetics, Pharmacodynamics, Solubility, Liposomes, Solid Lipid Nanoparticles, Nanostructured lipid carrier, Lipid-drug conjugate, Liposphere, Topical, Oral, Parenteral, Pulmonary, Protein/peptide.
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Authors:Bentham Science Books