Indopathy for Neuroprotection: Recent Advances

Author(s): Ambarish Kumar Sinha, Hagera Dilnashin, Hareram Birla and Gaurav Kumar * .

DOI: 10.2174/9789815050868122010016

Role of Withania somnifera (Ashwagandha) in Neuronal Health

Pp: 281-298 (18)

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* (Excluding Mailing and Handling)

  • * (Excluding Mailing and Handling)

Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

 Neurodegenerative disease refers to the progressive deterioration of neurologic function which leads to loss of speech, vision, hearing, and movement. It is also associated with seizures, eating difficulties, and memory impairment. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases due to the enormous adverse effects associated with pharmacological drugs. Withania somnifera (Ashwagandha) is a traditional Ayurvedic medicine, used in India as a general tonic. It contains withanolides, and phytochemicals that may have adaptogenic properties. Studies show that W. somnifera is a neuroprotective agent and can protect the brain from oxidative stress and inflammation. This explains its ability to protect from mood disorders. In this review, we have reviewed the available evidence of W. somnifera and its phytochemicals for neurodegenerative disorders. 

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