Frontiers in Anti-Infective Drug Discovery

Author(s): Monika I. Konaklieva, Balbina J. Plotkin

DOI: 10.2174/978160805158811001010269

Antibacterial Properties of Organosulfur Anti-Infectives: A Review of Patent Literature 1999-2009

Pp: 269-278 (10)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

A wide variety of organosulfur compounds that exhibit antibacterial properties are being patented. Functionally, organosulfur groups can act as metal chelators, powerful nucleophiles, or electrophiles depending on the local reaction environment. In this review of patent literature from 1999-2009, the reliance of these compounds on the reaction of the sulfur moiety with its biological target(s) will be discussed with regards to activity, specificity, and antimicrobial spectrum.

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