Omics Technologies for Clinical Diagnosis and Gene Therapy: Medical Applications in Human Genetics

Author(s): Hajra Qayyum* and Syeda Marriam Bakhtiar

DOI: 10.2174/9789815079517122010009

Regenerative Medicine

Pp: 79-92 (14)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Regenerative medicine (RM) is defined as a replacement and revival of human cells, tissues, or organs to reinstate or reconstruct their normal physiology. RM is regarded as a solution to provide healthy substitutes for a malfunctioning/failed organ or a tissue. It is emerging as the suitable substitute for organ transplantation. Transplantation seems impractical due to the limited availability of donors as significant disparities lie between the number of patients that require transplantation and the availability of organs from the donor, so there was a gap created. Therefore, to comply with these needs, RM has emerged as a new science to create biological replacements and exploit the body's ability of regeneration to recover and sustain normal function in diseased and damaged tissues. This chapter overviews RM in terms of adopted strategies, its clinical applications in organ engineering along with inherited challenges and their plausible solutions.

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