Nanoparticles-mediated Localized Controlled Drug Delivery Systems (LCDDSs)

Nanoparticles (NPs) and nanostructures can facilitate multianalyte detection, imaging and selective targeting of therapeutic molecules to cancer cells. This method increases the drug dose and maximizes at the anticipated location, and the healthy cells/tissues and their environments are protected simultaneously. To develop the targeting potential of therapeutic molecules, the surface and size characteristics of NPs should be improved, thereby enhancing their targeting effectiveness and circulation time. Here, we have highlighted recent advances and progress in smart stimuli-sensitive nanocarriers synthesized to improve the efficiency and localization of drugs compared to unmodified drugs. Multifunctional NPs could enhance the controlled release and targeting ability of drugs/therapeutic agents/biomolecules. The smart multifunctionality establishes versatile NPs, moreover, localized controlled drug delivery systems (LCDDSs) are promising and considerably increase the efficiency of therapy and diagnosis (theranosis) in pharmaceutical and biomedical science/engineering. 

Keywords: Cytotoxicity, Biocompatibility, Nanoparticles, Nanocarriers, Localized drug delivery, Triggered delivery.