Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Responsive and smart materials/biomaterials are responsive/sensitive to
signals originating from physiological systems, or to abnormalities originating from
pathological defects that can interact with or be triggered by the biological
environments. Responsive and smart materials/biomaterials are interesting in drug
delivery platforms/devices for developing next-generation accurate medicines. For a
deeper consideration of the different endogenous-responsive mechanisms of materials
and biomaterials, many researches have been established for the development of
micro/nano-fabrication, pharmaceutical science, biomedical engineering and materials
chemistry to improve endogenous-responsive biomaterials for various drug delivery
applications, such as medical bio-devices, drug delivery, localized controlled drug
delivery systems (LCDDS), tissue engineering and theranostics. This chapter reports
and discusses significant developments and progresses in the design and fabrication of
endogenous-responsive LCDDS that have the ability to control or regulate the
distribution of therapeutic agents (drugs) in response to a specific endogenous stimulus
(changes in redox, pH, enzyme and oxidation).
Keywords:
Endogenous stimuli, Enzyme-sensitive materials, Oxidation-sensitive materials, pH-sensitive materials, Redox-sensitive drug delivery, Stimuli-responsive biomaterials
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Authors:Bentham Science Books