Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
The 2019-nCoV RNA genome is highly protected by its unique structure
equipped with mechanistic spike proteins on its surface. Its RNA genome contains
almost all 14 Orfs encoding for at least 27 proteins. An Orf is a part of genetic material
that can undergo translation and produce proteins. Four structural proteins (SPs) likely
spike (S), envelope (E), membrane (M), and nucleocapsid (N) are present in 2019-
nCoV and afford its structure. In this chapter, we have discussed in detail the virology
of 2019-nCoV including structural proteins (SPs), accessory proteins, non-structural
proteins (NSPs), genomic structure, and its components. The role of SPs, accessory
proteins, NSPs of 2019-nCoV is discussed and this review also explains, how the
interaction of 2019-nCoV occurs with that of hACE2. Additionally, topics such as
stabilization of virus-binding hotspots on hACE2 by 2019-nCoV, the role of thioldisulfide interchanges in the interplay between 'S' protein and hACE2, and the
similarity (in terms of amino acid sequence homology) (%) of 2019-nCoV with SARSCOV are discussed.
Keywords:
Accessory proteins, hACE2, NSPs (non-structural proteins), Orf, RBD, Spike protein, Virology of SARS-COV-2.
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Authors:Bentham Science Books