Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Rheumatoid arthritis is a severe systemic autoimmune disorder with limited
option available for treatment and no curative therapy available at present. Rheumatoid
arthritis manifests clinically through polyarthralgia related to joint dysfunction, which
triggers the autoimmune responses associated with antibodies against the selfneoepitopes and causes the chronic arthritic attack. Bone destruction is an important
feature to understand the pathology of rheumatoid arthritis, which may lead to a serious
concern for the patient for living a quality life. Available drugs for rheumatoid arthritis
such as methotrexate, hydroxychloroquine, and sulfasalazine exert effects on bone
metabolism in immune cells and cytokines that result in relieving pain, improving the
quality of life but still, the chronic teratogenic and toxic effects are challenging in
management of anti-arthritic drugs. This chapter reviews the current trend of bioactive
compounds for the treatment of rheumatoid arthritis, which may lead to the
development of novel anti-rheumatoid arthritis agents.
Keywords:
Adjuvant-induced arthritis, Alkaloids, Anthocyanin, Bone destruction, Crystal-induced arthritis, Cytokines, Dietary therapeutics, Fatty acids, Fatty acid, Flavonoids, Immunosuppression, Inflammation, Polyphenols, Rheumatoid arthritis, Saponins, Triterpenoids.
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Authors:Bentham Science Books