Neurodegenerative Diseases: Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches (First Edition)

Author(s): Sarfraj Ahmad Siddiqui, Habiba and Md Arshad * .

DOI: 10.2174/9789815040913122010007

Parkinson Disease: Molecular Biology, Pathophysiology and Biomarkers

Pp: 71-87 (17)

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* (Excluding Mailing and Handling)

  • * (Excluding Mailing and Handling)

Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Parkinson disease is a progressive neurodegenerative disorder that affects motor control of the body. The disorder is associated with the loss of neurons due to formation of protein aggregates that leads to the development of apoptosis and degeneration of the neurons. The disease progresses slowly, making it difficult to identify it at early stage. But the availability of potential therapeutic biomarkers in analysis and early identification of PD is of great importance. The current review discusses here the molecular biology, pathophysiology and availability of potential biomarkers associated with the PD condition.

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