Abstract
Understanding the pathological findings and pathogenesis of Alzheimer's
disease has been ever-expanding and challenging. Oxidative stress resulting from
excessive free radicals that can be scavenged by the antioxidant system of our body has
been implicated in the initiation and progression of the illness. Neuronal oxidative
stress can induce the formation of amyloid-beta (Aβ) protein, and it has been found that
Aβ is involved in several intracellular pathways that orchestrate the cellular oxidative
stress, resulting in a vicious cycle. Several risk factors can lead to AD by increasing
neuronal oxidative stress. Therapy based on increasing and reinforcing the antioxidant
defense against free radicals has shown promising results. New approaches are being
developed, such as interventions targeting mitochondria and drugs that act through
numerous mechanisms to address the various ways through which oxidative stress
causes AD.
Keywords: Amyloid-beta protein, Antioxidants, Oxidative stress, Risk factors.
Related Journals
Current Molecular Medicine
Current Chemical Biology
Current Metabolomics
Current Indian Science
Glucolipid Metabolic Disorders
Related Books
Advances in Physicochemical Properties of Biopolymers (Part 1)
Advances in Physicochemical Properties of Biopolymers (Part 2)
Biochemical Mechanisms of Aluminium Induced Neurological Disorders
Biochemistry: Fundamentals and Bioenergetics
Biology and Chemistry of Beta Glucan Volume Title: Beta-Glucan, Structure, Chemistry and Specific Application
Biology and Chemistry of Beta Glucan Vol: 1 Beta Glucans - Mechanisms of Action
Cutting Edge Techniques in Biophysics, Biochemistry and Cell Biology: From Principle to Applications
Essential Techniques for Medical and Life Scientists: A Guide to Contemporary Methods and Current Applications with the Protocols: Part I
Essential Techniques for Medical and Life Scientists: A Guide to Contemporary Methods and Current Applications- Part II
