Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Understanding the pathological findings and pathogenesis of Alzheimer's
disease has been ever-expanding and challenging. Oxidative stress resulting from
excessive free radicals that can be scavenged by the antioxidant system of our body has
been implicated in the initiation and progression of the illness. Neuronal oxidative
stress can induce the formation of amyloid-beta (Aβ) protein, and it has been found that
Aβ is involved in several intracellular pathways that orchestrate the cellular oxidative
stress, resulting in a vicious cycle. Several risk factors can lead to AD by increasing
neuronal oxidative stress. Therapy based on increasing and reinforcing the antioxidant
defense against free radicals has shown promising results. New approaches are being
developed, such as interventions targeting mitochondria and drugs that act through
numerous mechanisms to address the various ways through which oxidative stress
causes AD.
Keywords:
Amyloid-beta protein, Antioxidants, Oxidative stress, Risk factors.
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Authors:Bentham Science Books