Pharmaceutical Chemistry and Production: An Introductory Textbook

Author(s): Samir Kumar Mandal and Rebeca Ghanta

DOI: 10.2174/9781681088891122010004

Antimalarial, Antibiotics, Antibacterial and Antifungal Drugs

Pp: 25-42 (18)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

This chapter deals with the class of aminoquinolines or quinolone
antimalarial, antibiotic, antibacterial and antifungal drugs. Brand names of the
antimalarial agent (e.g. Chloroquin, Primaquine), antifungal agent (e.g. Fluconazole),
antibiotic agent (Nalidixic acid, Norfloxacin, Chloramphenicol), antibacterial and
antifungal agents (Sulphonamides, Sulfamethoxazole, Sulphacetamide, Trimethoprim)
along with the uses, mode of action and side effects have been discussed in this
chapter. Various synthetic methods have shown for these drug molecules. Different
types of name reactions have included as the key for their synthesis.

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