Frontiers in Clinical Drug Research – Anti Allergy Agents

Author(s): Chetna Ameta*, Sunita Panchawat and Dharmendra

DOI: 10.2174/9789815040616122050005

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Nitrogen-containing Heterocycles as Anti-allergy Agents

Pp: 76-120 (45)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Nitrogen-containing heterocycles exhibit a diverse range of biological activities and are widely explored and utilized by the pharmaceutical industry for drug discovery. There are a lot of synthesized N-Containing heterocyclic compounds that showed antiallergic/antihistamine activities. A series of imidazole derivatives (Such as cimetidine), benzimidazole derivatives (Such as Astemizole, Bilastine, Emedastine,

Mizolastine, and Clemizole), and 2-methylpropanamide and benzamide derivatives of carboxyterfenadine are synthesized and evaluated as H1 antihistamine activity. Quinazolinone derivatives, pteridinones related compounds, and piperidine derivatives (such as Fexofenadine) also have strong antihistamine activity with a low sedative effect. Antihistaminic activity of the synthesized compounds was studied on the
histamine-induced contractions of guinea-pig ileum tissues.

Keywords:

Anti-allergic, Antihistaminic, Drugs, Heterocycles, Nitrogen.

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