Advances in Organic Synthesis

Author(s): Mario Komar and Maja Molnar * .

DOI: 10.2174/9789815039269122160004

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Application of Modern Green Chemistry Methods in the Synthesis of Quinolines, Quinazolines and Quinazolinones

Pp: 63-115 (53)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

In the last few decades, there is a constant demand for novel bioactive
compounds in all areas of pharmacy and medicine, thus increasing the demands for
their design and synthesis. Quinolines, quinazolines and quinazolinones, highly
bioactive heterocyclic compounds with a nitrogen core, have been employed in many
important drugs nowadays. Their synthesis often includes an enormous amounts of
different hazardous organic solvents, catalysts, as well as energy consumption. In the
last two decades, there is a growing interest in the application of different green
chemistry methods in different research areas, including synthesis. This chapter
describes their application in the synthesis of the above mentioned compounds.
Microwave-assisted, ultrasound-assisted, mechanochemical synthesis in the
combination with solvent-free synthesis and synthesis in deep eutectic solvents (DESs)
and ionic liquids (ILs) of quinolines, quinazolines and quinazolinones is described. All
mentioned green chemistry methods are gaining promising environmental and
economic benefits and are being a subject of many research these days.

Keywords:

Deep eutectic solvents, Mechanochemical synthesis, Microwaveassisted synthesis, Quinazoline, Quinazolinone, Quinoline, Solvent-free synthesis, Ultrasound-assisted synthesis.

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