The Evolution of Radionanotargeting towards Clinical Precision Oncology: A Festschrift in Honor of Kalevi Kairemo

Author(s): Irene Virgolini * .

DOI: 10.2174/9781681088655122010021

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Theragnostics in Austria

Pp: 232-245 (14)

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* (Excluding Mailing and Handling)

  • * (Excluding Mailing and Handling)

Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Over the past decades, Professor Kalevi Kairemo has been a well-known and
dear colleague with whom we have excellently cooperated, especially via the
international organisations IAEA (International Atomic Energy Agency) and The
WARMTH (World Association of Radiopharmaceutical and Molecular Therapy). The
work resulted in the construction of radiotracers using different modal systems,
including a variety of radiolabelled peptide analogues such as somatostatin,
cholecystokinin (CCK-2/gastrin), or prostate-specific membrane antigen (PSMA)
ligand for specific tumour targeting. Radiopharmaceuticals are produced at clinical
grade in dedicated laboratories for use in SPECT/CT or PET/CT studies. Patients
evaluated by SPECT/CT dosimetry studies are treated with high dose thera(g)nostics.
Radioiodine ablation therapy of thyroid cancer remnants, peptide receptor radionuclide
therapy (PRRT) of NET patients, and peptide ligand radionuclide therapy (PLRT) of
PC patients are today the most important therapeutic tools.

Keywords:

Peptide Receptor Radionuclide Therapy, Peptide ligand Radionuclide Therapy, Radioiodine Refractory Thyroid Cancer, Hormone Refractory Prostate Cancer, Neuroendocrine Tumours, Thera(g)nostics.

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