Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Currently, hepatocellular carcinoma (HCC) is the third leading cause of
mortality among cancerous diseases. It is a primary type of liver cancer possessing
unique features like solid malignant tumor type growth, leaky vasculature, and
angiogenesis. The success of conventional treatment in the management of HCC is
constrained due to unresponsiveness to particular approaches, drug resistance, systemic
side effects, and recurrence of malignancy. The development of nanotherapeutics offers
an impending key for overcoming these challenges. Nanotherapeutics utilizes
nanosized or nanostructured materials to attain particular therapeutic and
pharmacokinetic purposes. The diverse targeting strategies and site-specific drug
release patterns of this approach enlighten the hope for effective management of HCC.
Scientists have developed several nanomaterials like nanoparticles, nanogel, and
liposomes to deliver chemotherapeutic agents specifically to HCC sites with improved
efficacy, safety, and selectivity. Active targeting has remained most common and
effective in HCC management among active, passive, and stimuli-responsive targeting
strategies. Hopefully, some nanoformulations for HCC treatment have proved their
promising effects in clinical trials. In this chapter, an attempt is made to illustrate the
overview of HCC, the impact of nanotherapeutics, along with recent developments,
suitability, and challenges of various nanotherapeutic approaches for HCC
management.
Keywords:
Chemotherapy, Hepatocellular carcinoma, Nanomedicine, Nanoparticles, Primary cancer, Nanotheranostic, Selectivity, Targeting.
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Authors:Bentham Science Books