Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
The most relevant critical clinical picture in CVID19 patients is respiratory
failure, micro clots in various organs, disseminated intravascular coagulation (DIC) and
progressive multiple organ failure (MOF). The “hyperinflammation” or “cytokine
storm '' is the scenario in which the complement (included C5) attack is triggered. This
activity can be detected by the loss of expression of CD88 in the membrane circulating
neutrophils (PMN), and this loss of expression reflects the attack of the complement to
the rest of the organs and tissues, which is accompanied by a state of unmunoparalysis
that favors bacterial infection and sepsis. The drop in the expression of CD88 in
circulating PMNs can be a biomarker that announces this sequence of events, and is
anticipated between 48-72 hours before the installation of sepsis and / or the multiple
failure of organism. Under these conditions, the monitoring of PMN-CD88 can allow
the concomitant use of Eculizumab as a therapeutic strategy that aborts the complement
attack and avoids multiple organ failure in the critical patient, infected by COVID-19.
Keywords:
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Authors:Bentham Science Books