Abstract
The comprehensive chronological advancement and statistical account of
the recent developments and current scenario on antimalarial chemotherapy, in
particularly, based on various types of artemisinin analogues and their potential as
antimalarial agents have been schematically presented in this book chapter. These
studies had compared efficacies of various semi-synthetic artemisinin analogues with
that of standard reference drug artemisinin, β-Arteether and various other anti-malarial
drugs. Thus, this book chapter highlights the recent advancements and historical
developments observed in the medicinal chemistry of artemisinin since its discovery
during the past 49 years (1971-2020). Hence, this book chapter will serve as first-hand
information on artemisinin-based antimalarial peroxides to organic and medicinal
chemists, as well as biologist/pharmacologists working on anti-malarial drug discovery
and development.
Keywords: Antimalarial peroxides, Arteether, Artemisinin, Artesunate, Malaria, Multi-drug Resistant.
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