Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Cancer is the most dreadful disease and has significant health problems occurring worldwide. Cancer can arise from abnormal proliferation in a cell, and there are a diverse number of signaling pathways that regulate cell proliferation and its behavior. The signaling pathways contribute to the development and cellular homeostasis in cells. In diseases, especially cancer, developmental components of these pathways often become mutated or in many cases, overexpressed, which cause interruption or deregulation of cellular signaling. Cancer treatment action can target multiple signaling pathways and their molecular targets. This chapter provides an overview of the key pathways involved in tumor development and progression and components of the signaling pathways and their cross-talk associated with therapeutic implications.
Keywords:
Cancer, Death Receptor, Drug Targets, Insulin-like Growth Factor Receptor, Epidermal Growth Factor Receptor, Fibroblast Growth Factor Receptor, G –Protein Coupled Receptor, Membrane Receptors, Platelet-derived Growth Factor, Receptor Tyrosine Kinase, Signaling Pathways, Targeted Therapy, Therapeutic Strategies.
Recommended Chapters
We recommend
Authors:Bentham Science Books