Polyphenol Compounds as Potential Therapeutic Agents in Alzheimer’s Disease

Pp: 204-255 (52)

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Frontiers in Clinical Drug Research-Dementia

Volume: 2

Polyphenol Compounds as Potential Therapeutic Agents in Alzheimer’s Disease

Author(s): Érika Paiva de Moura, Alex France Messias Monteiro, Natan Dias Fernandes, Herbert Igor Rodrigues de Medeiros, Igor José dos Santos Nascimentos, Marcus Tullius Scotti, Francisco Jaime Bezerra Mendonça Júnior, Edeildo Ferreira da Silva-Júnior* and Luciana Scotti

Pp: 204-255 (52)

DOI: 10.2174/9789815039474121020007

* (Excluding Mailing and Handling)

Abstract

According to the World Health Organization (WHO), dementia is a syndrome that affects thoughts, memory, the ability to perform day-to-day activities, and behavior. Alzheimer's disease (AD) corresponds to almost 70% of dementia cases, affecting mainly the elderly over 60 years old, causing physical, psychological, social, and economic impacts. Whether of natural or synthetic origin, the polyphenols and their derivatives have great versatility in terms of biological activity, as can be seen in the literature, exhibiting different properties, such as anti-inflammatory, anti-tumor, anti-viral, anti-microbial, and others. Among therapeutic alternatives are polyphenols and their derivatives as a molecular class broadly studied against neurodegenerative diseases, including AD. This chapter consists of a literary review of some polyphenols and derivatives with proven activity against AD, thus showing their importance among the other molecular classes, when it comes to proposing new bioactive agents against AD. Many targets are studied for this disease, since the pathogenesis of AD requires clarification and approved drugs only delay the evolution of the disease, such as donepezil hydrochloride, galantamine, among others. In addition to encouraging new studies by relating polyphenols and derivatives targeting AD, this work can assist research groups by providing some recent studies that have proven this relationship. At the end of this research, it is possible to realize the importance and applicability of these compounds in AD.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1517
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59087164 and j.to_ip >=59087164 )) and ((j.from_date <= 1735780489 and j.to_date >= 1735780489 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 15748) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59087164 and j.to_ip >=59087164 )) and ((j.from_date <= 1735780489 and j.to_date >= 1735780489 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 15748) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59087164 and j.to_ip >=59087164 )) and ((j.from_date <= 1735780489 and j.to_date >= 1735780489 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 15748)
      500μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1548
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3138 and `b`.`banner_from_date` <= 1735780489 and `b`.`banner_to_date` >= 1735780489 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.02msalphaeurekaselec_live_10_06_2022Banner.php#189
      Bindings
      • 0: 1
      • 1: B
      • 2: 3138
      • 3: 1735780489
      • 4: 1735780489
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:189
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='0b4c7105fe1489c0e0459dc4fb5e1ba5'
      180μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._main_menu:13
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        iP0l9G6d2iKsoSXq5jOtl2alJFrjsMaXbhGfbjxv
        uc_cart_id
        0b4c7105fe1489c0e0459dc4fb5e1ba5
        _previous
        array:1 [ "url" => "https://beta.benthamscience.com/chapter/15748" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
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        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
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        response_headers
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        ClearShow all
        Date ↕MethodURLData
        #12025-01-02 01:14:49GET/chapter/15748111192