Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Chimeric antigen receptor (CAR)-T cell therapy has recently been introduced as a promising therapeutic T cell-based therapy. Autologous T cells are collected from the patient, engineered in vitro to express artificial chimeric receptors against a specific tumor antigen, and infused into the patient. The success of adoptive CAR-T cells for cancer immunotherapies, particularly in hematological malignancies, inspired researchers of the field. These armored T cells also showed a great potential to be used in the treatment of pediatric brain tumors and autoimmune diseases. In this chapter, we summarize the basics and developments of CAR-T cells from our previous review articles and then discuss the current progress in the pre-clinical and clinical application of CAR-T cells in brain tumors and autoimmune diseases.
Keywords:
Adoptive cell therapy, Autoimmune disease, Brain tumor, Cancer immunotherapy, CAAR, CAR-T, Glioblastoma, Regulatory T cell, Tumor antigen.
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Authors:Bentham Science Books