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SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Recent studies have demonstrated that tumor cells have hierarchical organization with cancer stem cells at the apex. Cancer stem cells, also termed cancer initiating cells, have self-renewal capacity and might not be sensitive to cytotoxic drugs. Thus, these cells may be responsible for the high frequency of relapse in many cancers, such as acute leukemias, brain and breast cancer. This chapter will approach the evidences of the presence of leukemia stem cells and the therapeutic perspectives to reach these cells.
Keywords:
Cancer stem cells, Hematopoietic Stem Cell (HSC), Leukemia Stem Cells (LSCs), Primitive Hematopoietic Cell, Normal Hematopoiesis, AML, CML, Epithelial–Mesenchymal Transition (EMT), Osteopontin (OPN), Therapeutic Opportunities.
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Authors:Bentham Science Books