Influenza: A Century of Research

Author(s): Irina Kiseleva and Natalie Larionova

DOI: 10.2174/9781681088440121010005

Influenza Virus Ecology and Evolution

Pp: 63-97 (35)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Influenza viruses undergo evolution by the shift (influenza A viruses) and the drift of envelope glycoproteins. Since predicting the direction of the antigenic evolution of influenza viruses is impossible, it is necessary to monitor wild viruses in nature. An important objective is to control the circulation of influenza viruses in natural reservoirs, interspecies transmission, especially the acquisition by avian influenza viruses and their ability to infect mammals, and detection of cases of stable transmissibility of such strains. In addition to antigenic evolution, it is necessary to identify and track the patterns of evolution of other biological properties of influenza viruses that might promote the evasion of viruses from the factors of nonspecific defense of the body and aggravate the epidemic process.

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