Download PDF FlyerAbstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
A number of reports implicated targeting TGF-a as a promising therapeutic target for the treatment of many types of cancer including prostate cancer. This cytokine not only have the ability to suppress cancer cell growth and proliferation during the early stage of cancer but to promote tumor progression and metastasis during the advance stage of disease. The elucidation of mechanism responsible for the TGF-a switch for a tumor suppressor to tumor promoting cytokine is critical for implementation of TGF-a as a promising therapeutic target for advanced stage of cancer towards tumor progression and metastasis.
Keywords:
TGF-β, prostate cancer, apoptosis, Smad-signaling, androgens, metastasis
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Authors:Bentham Science Books