Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Multicomponent reaction (MCR) is a type of reaction based on a mixture of three or more compounds or reagents leading only to one or a major molecule being able to form complex molecules with a high degree of control of the stereogenic centers in only one step. This methodology is also a useful tool in medicinal chemistry to produce a diversity of compounds for biological evaluation. Due to its importance, the exercises below focus on this technique.
Keywords:
Bioactive compounds, Chemical transformations, Combinatorial chemistry, Drugs, Exercises, Heteroaromatic compounds, Medicinal chemistry, Molecules, Multicomponent reaction (MCR), Reaction conditions, Reagents, Retrosynthetic analysis, Substances, Synthesis, Synthons.
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Authors:Bentham Science Books