Exercises in Organic Synthesis Based on Synthetic Drugs

Author(s): Marcus Vinícius Nora de Souza

DOI: 10.2174/9789811487569120010007

Nitriles

Pp: 150-164 (15)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Nitrile is a chemical function found in several drugs in the market for different kinds of diseases and can be transformed into several other functional groups such as ketones, aldehydes, carboxylic acids, amines, amides, and other functional groups. The use of nitriles is also advantageous in forming heteroaromatic nuclei with important applications in medicinal chemistry. In this chapter, the exercises are based on the use of nitriles to form a different nucleus.

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