Exercises in Organic Synthesis Based on Synthetic Drugs

Author(s): Marcus Vinícius Nora de Souza

DOI: 10.2174/9789811487569120010004

Identifying Drug Structure and Completing the Gaps

Pp: 70-113 (44)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

In this chapter, the exercises below are also based on two themes. The first has an objective of the identification of the structure of the drugs having information of the starting materials and reagents used. This activity also enables the reader to become familiar with different classical chemical transformations used in medicinal chemistry and with varying types of reagents, reaction conditions, and necessary intermediates. In the second theme, the exercises are based on a series of gaps in the synthesis of different drugs. Therefore, it is up to the reader to complete them. This type of exercise is a combination of the themes previously presented. It is necessary to identify the reagents' use, the reaction conditions employed, and the intermediates formed, besides the use of the concept of retrosynthesis.

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