Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
In this chapter, we will review some methods and platforms related to the diagnosis of Alzheimer’s disease (AD). The global prevalence of dementia and AD shows the urgent requirement of effective treatment, where an accurate and early diagnosis plays an important role. Apart from cognitive diagnosis that clarifies the cognitive deterioration of AD, abundant clinical studies have consistently recognised the core neuropathological features and related fluid biomarkers as utile indicators for the diagnosis and prognosis of AD and its preclinical stages. In order to enhance the accuracy of detecting these biomarkers, convinced methods and platforms are essential. Here, we summarised associated platforms, including imaging platforms (e.g., positron emission tomography (PET) and structural imaging), enzyme-linked immunosorbent assays (ELISA), and matrix-assisted laser desorption/ionisation – time of flight – mass spectrometry (MALDI-TOF-MS).
Keywords:
Amyloid-β (Aβ), Alzheimer’s Disease, Biomedical Modelling, Biomarker, Cerebroporomehcaincs, Dementia, Enzyme-linked Immunosorbent Assays (ELISA), Matrix-Assisted Laser Desorption/Ionisation – Time of Flight – Mass Spectrometry (MALDI-TOF-MS), MultipleNetwork Poroelastic Theory (MPET), Tau, Neuroimaging, Virtual Physiological Human (VPH).
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Authors:Bentham Science Books